View abstract. 2004;3(6):310-316. Teikari JM, Virtamo J, Rautalahti M, et al. The association between lung and prostate cancer risk, and serum micronutrients: results and lessons learned from beta-carotene and retinol efficacy trial. Skin Pharmacol.Physiol 2007;20(4):199-210. 2010;128(4):403-411. 2012;96(5):1223S-1233S. JAMA 2013;309(19):2005-2015. Prospective study of lutein/zeaxanthin intake and risk of age-related macular degeneration. 2012;107(3):350-359. WebLutein is concentrated in the primate retina, where together with zeaxanthin it forms the macular pigment. 2000;71(3):239-245. Influence of increased fruit and vegetable intake on plasma and lipoprotein carotenoids and LDL oxidation in smokers and nonsmokers. Br.J.Nutr. van Leeuwen R, Boekhoorn S, Vingerling JR, et al. View abstract. 2010;9:22. View abstract. View abstract. Am J Epidemiol 1999;149:801-9. View abstract. Ge XX, Xing MY, Yu LF, et al. Andersen, L. F., Jacobs, D. R., Jr., Gross, M. D., Schreiner, P. J., Dale, Williams O., and Lee, D. H. Longitudinal associations between body mass index and serum carotenoids: the CARDIA study. Abnet, C. C., Qiao, Y. L., Dawsey, S. M., Buckman, D. W., Yang, C. S., Blot, W. J., Dong, Z. W., Taylor, P. R., and Mark, S. D. Prospective study of serum retinol, beta-carotene, beta-cryptoxanthin, and lutein/zeaxanthin and esophageal and gastric cancers in China. View abstract. Serum antioxidants and age-related macular degeneration in a population-based case-control study. JAMA 1994;272:1413-20. Carotenoids and colon cancer. Thyagarajan, B., Meyer, A., Smith, L. J., Beckett, W. S., Williams, O. D., Gross, M. D., and Jacobs, D. R., Jr. Serum carotenoid concentrations predict lung function evolution in young adults: the Coronary Artery Risk Development in Young Adults (CARDIA) study. It may help decrease heart problems. Thurnham, D. I., Northrop-Clewes, C. A., Paracha, P. I., and McLoone, U. J. Kotagiri SR, Morde A, Rai D, et al. View abstract. Are supplements really necessary to achieve benefits? View abstract. Steinmetz KA, Potter JD. Invest Ophthalmol Vis Sci 1997;38:1795-801.. View abstract. View abstract. Clin.Chem. Retina 2010;30(8):1282-1293. The information in our articles is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. J.Nutr. 7-15-2001;391(2):160-164. Molldrem, K. L., Li, J., Simon, P. W., and Tanumihardjo, S. A. Lutein and beta-carotene from lutein-containing yellow carrots are bioavailable in humans. Antioxidant status and neovascular age-related macular degeneration. View abstract. Chopra, M., O'Neill, M. E., Keogh, N., Wortley, G., Southon, S., and Thurnham, D. I. Glabska D, Guzek D, Zakrzewska P, Lech G. Intake of Lutein and Zeaxanthin as a Possible Factor Influencing Gastrointestinal Symptoms in Caucasian Individuals with Ulcerative Colitis in Remission Phase. View abstract. Dreher, M. L. Pistachio nuts: composition and potential health benefits. are clickable links to these studies. The answer will tell you how much lutein youre getting. Dietary carotenoid intake and risk of developing preeclampsia: a hospital-based case-control study. Bone, R. A., Landrum, J. T., Guerra, L. H., and Ruiz, C. A. Lutein and zeaxanthin dietary supplements raise macular pigment density and serum concentrations of these carotenoids in humans. J Nutr 2006;136(5):1161-1165. Ophthalmology 2002;109:2272-8.. View abstract. Ferguson, L. R. and Schlothauer, R. C. The potential role of nutritional genomics tools in validating high health foods for cancer control: broccoli as example. 2012;25(5):523-527. Zhang W, Li W, Du J. View abstract. 1996;66(2):119-125. Chew, E. Y., Clemons, T., SanGiovanni, J. P., Danis, R., Domalpally, A., McBee, W., Sperduto, R., and Ferris, F. L. The Age-Related Eye Disease Study 2 (AREDS2): study design and baseline characteristics (AREDS2 report number 1). Albanes D, Virtamo J, Taylor PR, et al. Lutein supplements have been used safely by adults in doses up to 15 to 20 milligrams daily for as long as two years without any serious side effects. Rock, C. L., Flatt, S. W., Wright, F. A., Faerber, S., Newman, V., Kealey, S., and Pierce, J. P. Responsiveness of carotenoids to a high vegetable diet intervention designed to prevent breast cancer recurrence. 26th ed. Sin, H. P., Liu, D. T., and Lam, D. S. Lifestyle modification, nutritional and vitamins supplements for age-related macular degeneration. View abstract. Mol.Nutr.Food Res. Carotenoids and antioxidants in age-related maculopathy italian study: multifocal electroretinogram modifications after 1 year. View abstract. PLoS One 2019;14(12):e0227048. View abstract. Brown L, Rimm EB, Seddon JM, et al. Nutrients. It is certified by the National Eczema Association, meaning it is safe for those with eczema or sensitive skina testament to its mildness. Malila, N., Virtamo, J., Virtanen, M., Pietinen, P., Albanes, D., and Teppo, L. Dietary and serum alpha-tocopherol, beta-carotene and retinol, and risk for colorectal cancer in male smokers. Johnson, E. J., Chung, H. Y., Caldarella, S. M., and Snodderly, D. M. The influence of supplemental lutein and docosahexaenoic acid on serum, lipoproteins, and macular pigmentation. Association between dietary carotenoid intakes and the risk of asthma in adults: a cross-sectional study of NHANES, 2007-2012. Amount of fat in the diet affects bioavailability of lutein esters but not of alpha-carotene, beta-carotene, and vitamin E in humans. Invest Ophthalmol.Vis.Sci. View abstract. Spread supplemented with moderate doses of vitamin E and carotenoids reduces lipid peroxidation in healthy, nonsmoking adults. Landrum JT, Bone RA, Joa H, et al. View abstract. That said, possible lutein and zeaxanthin side effects can include harmless yellowingof the skin calledcarotenemia and an upset stomach/vomiting if you take too much. The Effects of Lutein and Zeaxanthin Supplementation on Brain Morphology in Older Adults: A Randomized, Controlled Trial. Invest Ophthalmol.Vis.Sci. Med Hypotheses 1983;12:239-51. Maternal lutein and zeaxanthin concentrations in relation to offspring visual acuity at 3 years of age: The GUSTO Study. Optometry. Am J Epidemiol 1999;149:801-9. Cancer Sci. Neonatology. Nutr.J. Clin Sci (Lond) 2002;102:447-56. Lutein improves visual function in some patients with retinal degeneration: a pilot study via the Internet. View abstract. Arch Ophthalmol 1993;111:104-9.. View abstract. Falsini, B., Piccardi, M., Iarossi, G., Fadda, A., Merendino, E., and Valentini, P. Influence of short-term antioxidant supplementation on macular function in age-related maculopathy: a pilot study including electrophysiologic assessment. View abstract. 2013 Feb 15;5(2):543-51. This can increase their risk for developing deficiencies and experiencing disorders as they age. Curr Dev Nutr 2021;5(10):nzab123. Therapeutic Research Faculty 2020. Juturu V, Bowman JP, Deshpande J. Other benefits of lutein for eye health include: When it comes to eye health, every person is different in terms of how much lutein is most beneficial. Invest Ophthalmol Vis Sci. Tan, J. S., Wang, J. J., Flood, V., Rochtchina, E., Smith, W., and Mitchell, P. Dietary antioxidants and the long-term incidence of age-related macular degeneration: the Blue Mountains Eye Study. 2013;98(3):778-86. View abstract. View abstract. However, most studies show that benefits are greatest when someone consumes 10 milligrams of lutein per day or more (along with about two milligrams of zeaxanthin perday). JAMA 1994;272:1413-20. Bernstein, P. S., Ahmed, F., Liu, A., Allman, S., Sheng, X., Sharifzadeh, M., Ermakov, I., and Gellermann, W. Macular pigment imaging in AREDS2 participants: an ancillary study of AREDS2 subjects enrolled at the Moran Eye Center. Lutein is an antioxidant often used in the treatment or prevention of eye diseases. Invest Ophthalmol.Vis.Sci. I. Lopresti AL, Smith SJ, Drummond PD. Sabour-Pickett, S., Nolan, J. M., Loughman, J., and Beatty, S. A review of the evidence germane to the putative protective role of the macular carotenoids for age-related macular degeneration. In fact, there are more than600 different types of carotenoids found in nature, but only about 20make their way into the eyes. Goltz, S. R., Campbell, W. W., Chitchumroonchokchai, C., Failla, M. L., and Ferruzzi, M. G. Meal triacylglycerol profile modulates postprandial absorption of carotenoids in humans. Tan AC, Balaratnasingam C, Yannuzzi LA. View abstract. Nutr Res 2001;21:797-809. The human body cannot synthesize lutein or zeaxanthin on its own, which means we must obtain these important nutrients from our diets (or, in some cases, supplements). Zhao, X., Aldini, G., Johnson, E. J., Rasmussen, H., Kraemer, K., Woolf, H., Musaeus, N., Krinsky, N. I., Russell, R. M., and Yeum, K. J. While the research is still in its early stages, taking lutein three times weekly for up to two years has been shown to improve vision in older people who already have cataracts. WebOverview. A possible role for lutein and zeaxanthin in cognitive function in the elderly. View abstract. 2007;16(10):2008-2015. Zeaxanthin and lutein are two powerfulcarotenoid antioxidants that are mostly found in brightly colored foods like fruits and vegetables. View abstract. Just one drop of this thick cream will moisturize dry hands or itchy eczema spots. View abstract. JAMA Ophthalmol 2022. Gale, C. R., Hall, N. F., Phillips, D. I., and Martyn, C. N. Lutein and zeaxanthin status and risk of age-related macular degeneration. A., Kardinaal, A. F., Van, Poppel G., and Van, Norren D. Lens aging in relation to nutritional determinants and possible risk factors for age-related cataract. J Nutr 2002;132:3668-73. Chew EY, Clemons TE, Agrn E, et al . There's 44 mg of lutein in one cup of cooked kale, 26 mg per cup of cooked spinach, and 3 mg per cup of broccoli. Lutein is an orange-colored nutrient. Med.Sci.Sports Exerc. According to the Centers for Disease Control and Prevention (CDC), Americans get American Macular Degeneration Association, Top 7 Ways Carrot & Carrot Juice Benefit Your Body, Daniel Fast: Benefits for Your Spiritual, Emotional and Physical Health, 15 Fermented Foods for a Healthy Gut and Overall Health, 9 Proven Black Seed Oil Benefits that Boost Your Health, L-Glutamine Benefits Leaky Gut & Metabolism, Chia Seeds Benefits: The Omega-3, Protein-Packed Superfood, Apple Cider Vinegar Benefits for Weight Loss, Skin Health, Cholesterol & More, Is Lamb Healthy? Naylor CD, O'Rourke K, Detsky AS, Baker JP. Visual acuity at 3 years of age: the GUSTO study SJ, Drummond PD than600 types. And retinol efficacy trial of developing preeclampsia: a Randomized, Controlled trial and lessons learned from beta-carotene and efficacy. Zeaxanthin concentrations in relation to offspring visual acuity at 3 years of age: the GUSTO.! 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